Rockefeller University Research Assistant | Laboratory of Molecular Neuro-Oncology in New York, New York
RNA is the driving force of biological complexity, determining which genes any given cell expresses at specific times and under specific circumstances. Darnell developed high-throughput sequencing and crosslinking methods to investigate how RNA binding proteins (RBPs) modulate gene expression. He discovered neuron-specific RNA-binding proteins in the mammalian brain, and studies their link to intellectual function and human disease.
Our groupfocuses on characterizing the molecular mechanisms that underlie phenotypes of rheumatoid arthritis (RA). In previous studies we have used machine learning to integrate rheumatoid arthritis gene expression profiles with synovial histology features to provide insight into RA disease subsets (Arthritis and Rheumatol, 2018). We noted the persistence of histologic and transcriptional evidence of subclinical synovial inflammation in some RA patients in clinical remission (Arthritis and Rheumatol, 2019). Our group has also uncovered synovial histology associations of morning stiffness (Arthritis and Rheumatol, 2020). We have developed methods to empower patients to participate in dense longitudinal genomics studies from home and used this approach to gain insights into the immune events that lead to rheumatoid arthritis flares (NEJM, 2020).
Helping to collect, store, process and organize clinical blood and tissue samples
Using basic molecular biology and biochemical techniques including:
RNAseq library preparation
flow cytometry and sorting
Bachelor's degree, with educational emphasis in Life sciences, molecular biology or biochemistry
Background knowledge of molecular biology is preferred
Basic knowledge of tissue culture and laboratory practice
An ability to give full attention to experiments and keep accurate and accessible records
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The salary of the finalist selected for this role will be set based on various factors, including but not limited to organizational budgets, qualifications, experience, education, licenses, specialty, and training. The hiring range provided represents The Rockefeller University's good faith and reasonable estimate of the range of possible compensation at the time of posting.
Compensation Range: Min
Compensation Range: Max
Job Locations US-NY-New York
Position Type Regular Full-Time