Rockefeller University Research Assistant in New York, New York
Job Title Research Assistant
Laboratory / Department Molecular and Cellular Neuroscience
The Laboratory of Molecular and Cellular Neuroscience studies the molecular defects responsible for neurological and psychiatric disorders including Alzheimer's disease, major depressive disorder, Parkinson's disease, and obsessive compulsive disorder, as well as the molecular mechanisms by which neuro- and psychoactive drugs produce their pharmacological actions in these disorders. Research from the laboratory has demonstrated that most neurotransmitters and neuromodulators achieve their actions and interactions on post-synaptic neurons through a process called "slow synaptic transmission." This process involves activation of highly complex signal transduction cascades. For the last 10 years, the group has applied this knowledge and developed a state-of-the-art methodologies (eg. BacTRAP), to the study of the molecular pathways behind various neurological and psychiatric disorders.
The Research Assistant will be involved in biochemistry and evaluation of small molecules in cells and in animal models at the interface of chemistry and biology. Will work on assay development under PI's supervision, perform high-throughput screening, and evaluate compounds using in vitro and in vivo models. Will maintain and work with cells and mouse models.
Bachelor's degree in science required; educational emphasis in biochemistry or chemistry preferred. Prior hands-on training with cell culture, ELISA, and Western blotting required. Experience with assay development, performing drug screening, and in vitro and in vivo evaluation of compounds will be helpful.